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ROS and RNS constitute vital small-molecule mediators within the body, and their excessive production disrupts the bodys antioxidant defense systems, triggering a severe oxidative stress response [34] (see Fig

, Gebhardt R., and Hamprecht B

Neuroprotective effect of a multistrain probiotic mixture in SOD1G93A mice by reducing SOD1 aggregation and targeting the microbiota-gut-brain Axis

For each of these two experimental comparisons, we took advantage of the odIs131[hif-1::gfp] transgene, which rescues hif-1 mutants, to provide an additional experimental dataset that reduced unrelated genetic background effects